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KMID : 0602819990050020119
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Korean Journal of Bronchoesophagology
1999 Volume.5 No. 2 p.119 ~ p.126
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The Modulation of Squamous Cell Differentiation by Retinoids in Human Squamous Cell Carcinoma Xenografts
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김상윤/Sang Yoon Kim
유승주/유근식/주준범/최두영/남순열/Seoung Joo Yoo/Keun Sik Yoo/Joon Bum Joo/Doo Yung Squamous Cell Carcinoma Xenografts
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Abstract
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Objectives : To analyze the effect of retinoids on the differentiation in HNSCC
xenografts.
Materials and Methods : RA (20mg/kg) or 13-cis-RA (60mg/kg) was orally
administered once in a day for 30 days in the xenograft model we prepared using
athymic nude mice with AMCHN-4 and -6. We carried out H & E staining and
immunohistochemical staining with the monoclonal antibody against involucrin and
cytokeratin 10.
Results : Both RA and 13-cis-RA were found to suppress the differentiation of
AMC-HN-4. Interestingly, RA enhanced the differentiation of AMC-HN-6, although
13-cis RA did not exhibit any effect on the differentiation. These results suggest that in
vivo effect of retinoids on the HNSCC growth and differentiation might be various.
Retinoids-induced P450 in AMC-HN-6 might be one of the mechanisms to explain the
reason why the retinoids exhibit various functions in the HNSCC.
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KEYWORD
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